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Bioinformatics : Recent Questions and Answers (Page 16)

Find answers to your questions about Bioinformatics or help others by answering their Bioinformatics questions.

Is there a way to measure cell line similarity using python?

I have a list of cell lines that should be compared against another list of cell lines as pairs. I am trying to find a way in order for me...

Asked on 07/22/2021 by Yousef

1 answer

How to convert a SDF molecular structure file to a pandas dataframe with Python?

What is the best python tool to convert a SDF file to a structured data frame (pandas.DataFrame). Similar to Molconvert from ChemAxon? SDF can have different datafields for each compound...

Asked on 07/21/2021

1 answer

cmapPy exception

I'm trying to read gctx files with cmapPy. This is my code:from cmapPy.pandasGEXpress.parse_gct import parsefrom cmapPy.pandasGEXpress.write_gct import writeparse("C:/Users/User/Desktop/gctx/CAS9_BASELINE_LEVEL3_BING__n10721x10174.gctx")This is the error:(base) C:UsersUserDesktophello>D:/anaconda/python.exe c:/Users/User/Desktop/gctx/readgcxtx.pyTraceback (most recent...

Asked on 07/20/2021 by blue bells

1 answer

Timeout when downloading the ncbi nr blast database

I am experiencing timeout problems when downloading the NCBI nr preformatted blast database using the update_blastdb script (version 504861). I run the script with the following paramtersupdate_blastdb --decompress --passive...

Asked on 07/19/2021 by C. Zeil

2 answer

Understanding "Measurement of mRNA abundance using RNA-seq data" by Wagner et al 2012

I'm trying to understand why RPKM is not an appropriate way to normalize for RNA seq (I understand the general idea, but I'd like to gain a deeper understanding). So...

Asked on 07/19/2021

1 answer

Understanding ViennaRNA RNAdistance scoring table

I'm trying to compare the output of 2 different algorithms of RNA structure prediction(my implementation of Nussinov vs RNA-mfold algorithm) using the RNAdistance algorithm that is...

Asked on 07/18/2021

1 answer

Viral genome finishing

I have assembled poxvirus genome using Ray. The assembly is good. Out of several thousand contigs I got, I was able to get one scaffold using Contiguator tool, which is...

Asked on 07/17/2021

1 answer

Installing HiC-Pro issues

I am setting up a HiChIPseq pipeline, but installing software necessary for the HiC side of things has been unbecoming. Both my PI and I have tried to install Hi-C...

Asked on 07/16/2021

2 answer

“IndexError: list index out of range” in snakemake

I am trying to establish pipeline in snakePipes and while running DNA mapping I got next IndexError error.(snakePipes) ~ $ DNA-mapping -i /Volumes/HD2/snakePipes_CHIP/ChiPseq -o /Volumes/HD2/snakePipes_CHIP/ChiPseq1 --mapq 5 -j 10...

Asked on 07/15/2021 by Vitaly

0 answer

How to remove sequences from a fasta file using a sequence ID list which contains a space within the id?

I have a fasta file that contains sequence reads and sequence id file that needed to be removed from the fasta file. I have done this earlier, but since id...

Asked on 07/15/2021

2 answer

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