What use-cases show the consequentiality of MiKTeX's not using Kpathsea?

Unlike texlive, MiKTeX does not use Kpathsea. From a user perspective, it seems to me this makes the choice between MiKTeX and texlive (and other Web2C implementations of TeX and friends) far more consequential than a back-end matter (security, network clients vs servers, 32bit vs 64bit, multi-user vs single user, etc.; see a lot of the discussion in What are the advantages of TeX Live over MiKTeX?)

As an example, a user might have latex code that assumes they can always reach out to other paths descending from their home directory via string~ (as suggested by David Carlisle’s answer in Reference file relative to the home directory). But because MiKTeX does not use Kpathsea it will not expand string~, and so all that code breaks in MiKTeX Handling tilde for the home directory in latex, Windows 10, MiKTeX 2.9

What other use-cases has this community encountered where it matters that MiKTeX has chosen not to use Kpathsea?