Texmaker not saving settings

I had the very same problem. For me the reason was that I copied/installed the TexMaker binaries (from a 5.02 USB version of TexMaker) into my "Programs" folder. This folder is write protected by the Windows OS. The INI-file settings will get stored next to the binaries of TexMaker. So, they can not be written without raising the UAC rights of TexMaker.

Solution for me:

1. Go to the "texmaker.exe" binary somewhere in the "Programs" folder, right click it in the Explorer and choose "Run as administrator".
2. Apply some settings and save them. Now those settings will get written.

Please note that those lower UAC rights also apply in cases, where you start some TEX-files directly from the Explorer after setting the "standard TEX-file linked application".

I do not know if this a special issue of the USB version of texmaker or a general one.

Cheers!

There is a save button. Maybe its not being displayed because of the display settings.

Go to display settings in the settings app, There is an option called scale and layout. Change it to something less than the current value. 150% is recommended so try setting it to 100% and open the configure window in TeXmaker. Now you should be able to see a save button at the bottom.