First appearance of the shtick of mutants who are shunned?

I just finished reading The Chrysalids, a 1955 book by John Wyndham about a world after a nuclear apocalypse in which people superstitiously kill or exile mutants.

The idea of ionizing radiation causing scary or weird mutations is obviously one of the most commonly occurring SFnal ideas of the 1950’s. Wyndham’s idea of people shunning or exiling the mutants also doesn’t seem to have been at all trailblazing at the time, since Heinlein did the same thing in the 1941 Orphans of the Sky.

Was Heinlein the first to come up with the shun-the-mutants shtick? 1941 actually seems surprisingly early for this idea.

As late as 1946, John Hersey’s book Hiroshima seems to have surprised the general public by documenting the fact that ionizing radiation could kill people. (Lesley M.M. Blume recently published a book about this.)

Clarification: This question is specifically about mutations induced by high levels of ionizing radiation.