Again, this will depend on which version of the canon hero you are reading about. The most classic interpretation of the character, the Silver Age Superman also known as the Pre-Crisis Superman, was completely powered by solar energy.

• Meaning as long as he was under a yellow sun, he didn't need to do anything that resembled a biological process, no eating, sleeping, breathing or excreting of any kind; he was more like an energy being wearing flesh. He appeared to be for all intents and purposes a being powered completely by his body's catalytic response to solar energy.

• Under an orange or lower energy sun, he tired more easily and was capable of being injured. He healed slower as well. Under a red sun, he appeared to be Human in all the ways that mattered.

• Of course, he was completely capable of eating food and processing it normally and his invulnerability included the consumption of toxic materials or poisonous foods. He could eat any kind of food with no ill effects as long as the yellow sun provided him with his invulnerability.

• He could also breathe in toxic fumes and contain them within his lungs with no ill effects long enough to clear a space of the fumes and fly them into space before releasing them.

• This probably meant he would be immune to the effects of toxic drugs or powerful narcotics since his body only seemed to be affected by things native to his Kryptonian physiology.

The physics for why the Silver Age Superman was completely invulnerable, inside and out, were never completely explained (no surprise) so we were forced to accept his invulnerability meant he was proof against most environments and toxins without question. Only under the presence of Kryptonite (of a variety of colors) or the energies of Chaos magic would he be susceptible to any kind of toxin, drug, or biological agent.

Post-Crisis Superman seemed a bit more human and mentions more than once:

• He did need to breathe, just not very often and could hold his breath for a very long time, hours or even days if he needed to. (His body must not NEED oxygen at the same rate ours did, supplementing solar energy for whatever metabolic processes needed oxygen. He never notes whether it was painful to hold his breathe for such extended periods. He has worn a spacesuit and used compressed oxygen tablets when forced into space for extended periods.

• He notes he needed to sleep for the same reasons we do, to give his mind a chance to rest and process information through dreaming. He talked about going long periods without sleep noting reduced efficiency if he went longer than a month or two. (The clinical safe record for humans is about 11 days.)

• Post Crisis Superman was known to eat, mostly with his friends and family, but it was never made clear whether he NEEDED to eat. Since eating is both about repairing tissue and providing energy to the body, both things handled by his solar energy process, it is conceivable, Post Crisis Superman had no reason to have to eat other than enjoying the food and the company.

The Modern DCnU Superman has as yet not revealed whether he needs to eat, sleep or breathe long term. I suspect DC will continue with the tradition of having Superman emphasize the SUPER while minimizing the MAN aspect of the character.