How to patch C# binary?

I have C# binary. I was able to use dnSpy to decompile it, and analyze. The binary was obfuscated with xenocode obfuscator.

I figured out that I can directly manipulate IL instructions if I just find correct instruction offset, and replace instruction byte(s).

Original bytes and C# code (replaced with letters so it is readable):

a.b().c.d = (int)e.f;

 06 6F A0010006 6F 9302000A
 ^  ^  ^        ^  ^-------- T2
 |  |  |        ----------- callvirt to set_d
 |  |  -------------------- T1
 |  ----------------------- callvirt to get_f
 -------------------------- ldloc.0

What I want to achieve and resulting bytes:

a.b().c.d = 6;

 1C 00 00000000 6F 9302000A
 ^  ^           ^  ^-------- T2
 |  |           ----------- callvirt to set_d
 |  |  
 |  ----------------------- 5x nop, so the length of file is same
 -------------------------- ldc.i4.6

I am able to decompile changed binary without error, and I can observe my changed instructions, but when binary executes this region, it dies. Any ideas?