How to reduce large, agressive color noise?

Apparently, this is an issue with sequator. I tried stacking the images with DeepSky Stacker, and the result is a lot better:

100% view from LR, Exposure +2EV (Sequator used an auto exposure function which seems to lack in DSS - or, more likely, I just did not see it as I only tried the programm for about an hour - so the image came out a lot darker. It is still very noisy (but consider, I had only 6 images from a MFT camera at its highest ISO), but it can be reduced at least:

The same image with color and luminance NR both at 50.

I am not sure why DSS has better results here. I assume that Sequator had troubles with detecting the noise in the images and produced a stack result that still was very noisy. I also have to mention that the Noise in the Raw images was the most extreme that I have ever seen - this includes ISO 25600 at my Beginner APS-C DSLR.

This is by no means a "bashing" of Sequator. I find the programm to be somewhat more intuitive than DSS and I have used it with great results. Another practical feature is that it can automatically freeze the foreground.

You have 2 issues poor signal to noise ratio and motion blur (of the sky rotation) you will need to deal with.

Stacking frames helps add more signal but obviously not enough, but is hopefully compensating for the motion blur.

I have read somewhere that with a 50mm lens you can take up to 30 second exposures before motion blur becomes a problem.

So I would suggest reducing your iso (to maybe 800-1600 depends on how good your camera sensor is) and take longer exposures say 10 seconds. (Try several different variations)

Make sure you use a remote shutter trigger so you don't knock the camera between frames. Which will make it easier for your software to stack the images.

The higher temperatures increase sensor noise. In telescopes they will sometimes cool sensors with liquid nitrogen! I don't know if it would work but you could try chilling your camera in the fridge (not freezer). You could try putting it into a ziplock bag and chill it for a couple of hrs. Take out the batteries first as they don't like the cold. YMMV, be careful you don't void your warranty etc etc.

Also if you can, use an fstop of 5.6 - 8 to get the least lens and diffraction blur.

At this point you're gonna have to rely on moderate-to-severe computational photography methods to recover anything useful out of it.

The only thing that seems practical at the moment is just taking lots of frames and stacking them.

More "experimental" approaches might use something like compressed sensing or machine learning, but you're not gonna find any easy-to-use solutions for that. Here's an example: https://discuss.pixls.us/t/got-an-image-problem-go-see-the-image-doctor/14518