Exploit failed [unreachable]: Rex::ConnectionTimeout The connection timed out(remote host ip)

I have a similar issue , The problem was with lhost and Lport Use

Set LHOST 'attacker ip'

Set LPORT 'port number'

This may solve your issue

I had the same issue before. It turned out that the culprit was that specific port on the remote host is in use.

My workaround at the time was rebooting the remote machine. This can happen when you have previously opened a session and the port is still in LISTEN mode.

most probably a firewall.

a good firewall will block outgoing connections, just like most firewalls block incoming connections

if the local firewall does not allow outgoing connections to port 4444 that wont work

perhaps try using a basic port like 80 or 443

You asked this question and it was downvoted before. There could be a lot of reasons for this happening, your question is too broad, and lacks a lot of relevant information. For example, can you ping that host, is it running a firewall, it is vulnerable to that exploit. What you are experiencing is the host not responding back after it is exploited. This could be because of a firewall on either end (the attacking machine, the exploited machine). I would start with firewalls since the connection is timing out. From there I would move and set a different "LPORT" since metasploit tends to act quirky at times. E.g., set LPORT 2468. If that doesn't work, then jump on the metasploit forum and ask there, you'll likely get an accurate explanation.