Gear Design - Hunting tooth

Depends on the quality of your finished gear, both micro (surface finish) and macro (tooth runout, spacing, etc). Improper meshes will ultimately cause vibration in your system, if it's bad enough it will be pretty loud. Also, if you have an oversized tooth on your pinion and the mating tooth space on the gear is undersized you'll increase the stresses and likelihood of failure.

For lower quality gears hunting would be preferred so that the pinion and gear wear evenly.

For decent quality gears with respect to load it's less of an issue. And typically everyone else working with them will prefer an integer ratio.