How to choose TVS/ ESD for sensitive application?

R3 and R4 serve for this purpose, they limit current through the in-built ESD diode which is 5mA maximum. V=180k*5m= 900V.

Using standard TVS may spoil the measurement due to leakage currents.

Read the document:

INPUT PROTECTION All terminals of the AD8232 are protected against ESD. In addition, the input structure allows for dc overload conditions that are a diode drop above the positive supply and a diode drop below the negative supply. Voltages beyond a diode drop of the supplies cause the ESD diodes to conduct and enable current to flow through the diode. Therefore, use an external resistor in series with each of the inputs to limit current for voltages beyond the supplies. In either scenario, the AD8232 safely handles a continuous 5 mA current at room temperature. For applications where the AD8232 encounters extreme overload voltages, such as in cardiac defibrillators, use external series resistors and gas discharge tubes (GDT). Neon lamps are commonly used as an inexpensive alternative to GDTs. These devices can handle the application of large voltages but do not maintain the voltage below the absolute maximum ratings for the AD8232. A complete solution includes further clamping to either supply using additional resistors and low leakage diode clamps, such as BAV199 or FJH1100. As a safety measure, place a resistor between the input pin and the electrode that is connected to the subject to ensure that the current flow never exceeds 10 µA. Calculate the value of this resistor to be equal to the supply voltage across the AD8232 divided by 10 µA.