Is it possible to modify or replace the basic network of YOLO?

I have an idea to adapt YOLO algorithm to my application, the original YOLO algorithm is for image classifications, which have 24 convolutional layers with output class of 1000, is it possible to replace the basic network of YOLO with Alexnet or Resnet or the custom network structure designed by myself? Noted that my application have input shape of 500 * 10000 * 1 and only 4 classes for classification.