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SARS-CoV-2 : does vaccination provide a better immunity than being sick and recover?

Biology Asked on May 12, 2021

I recently read in the news that countries are thinking to offer a "green passport" based on the vaccination against SARS-CoV-2, allowing vaccinated people to do things with less restrictions than the non-vaccinated :

New York Times

BBC News

Bloomberg

IATA

If those passports are to be put in place, why do they not include people that were exposed naturally to SARS-CoV-2, this number being bigger days after days (60 millions people, 17/02/2021) ?

Does that mean that vaccines offer more immunity than being exposed naturally to SARS-CoV-2 and recover ?

My questions don’t address the ethical aspect of implementing a "green passport", I’m only trying to figure out if vaccination offers more immunity than being exposed to the virus. A possible answer to this question can simply be "we don’t know so far" because of the lack of feedback on a long term view.

2 Answers

As @MikeyC and @jamesqf pointed in the comments, vaccines are better documented than the actual cases, whereas qualifying the immunity conferred by having recovered from Covid-19 would require large cohort studies.

However, one can follow up thir argument in many ways:

  • It would be reallys urprizing, if large-scale cohort studies have not been udnerway or already available by now: while nationwide testing may still be lacking in many countries, masive and repeated testing campaigns in specific regions are not a rarity by now. (see, e.g., here and here)
  • Hospitalization is not a necessary requirement for attesting a covid case - one could test unvaccinated persons for the presence of the Covid-specific antibodies.
  • There is much still unknown about the vaccines themselves - particularly about whether the immunity conferred is a lasting one, and whether.
  • Moreover, the fact that many people might have lived light cases of Covid does not make it easier for attesting the efficacy of the vaccines. Public authorities openly warn that the vaccine might be inefficient and a vaccinated person might be still a carrier of the disease.

In other words, "we don't know" is the most likely answer.

As the OP, I forgo the ethical issues raised by the "green passport" - these are not only those related to the restrictions on the individual freedom, but also the discrimination against the individuals to whom the vaccine is counter-indicated (e.g., allergics, pregnant women, people with weakened immunity, etc.)

Correct answer by Vadim on May 12, 2021

It is said vaccines are over 90% effective. But I think natural obtained antibodies from Covid-19 and recovery offer more immunity than vaccines. The problem is that no pne can be sure to survive the infection.

Answered by LeadingBiology on May 12, 2021

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