Biology Asked by Francesca on August 6, 2021
The bacterial growth has 3 main stages: lag-phase, log-phase and stationary phase. I was wondering in which one of them penicillin can inhibit the growth of the cellular wall of bacteria and why.
I was thinking that the respons would be lag and log phase, because at these points bacteria multiply the most, while in stationary phase most of the bacteria are in adult form with a well formed bacterial wall already, but I’m not quite sure.
This is a really good question that requires you to appreciate a few different details and to overcome a few implicit assumptions that you might perhaps have.
You can have mature or immature bacteria at any stage of "bacterial growth", with either fully formed walls, or with none. This understanding should answer your question partially.
Here are a few more things to consider, for a more complete understanding:
This is more or less very standard knowledge that is easy to look up. Wikipedia's entry on penicillin is a good place to orient yourself if you already haven't.
Correct answer by S Pr on August 6, 2021
Penicillin is a beta lactam antibiotic that inhibits Transpeptidase enzyme ( Penicillin binding protein). Transpeptidase is required for the cross linking of murein monomers required for cell wall synthesis.
So as Penicillin binds to Transpeptidase it does not let it involved in cross linking of murein monomers and hence cell wall synthesis can't be completed. This is how Penicillin inhibits bacterial growth .
Now the phases ( lag ,log , stationary) you mentioned are used when a culture of bacterial colonies is grown and not used for a single bacterium .
Answered by Rahul Dhillon on August 6, 2021
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