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Hybridization capture: Array-capture vs. in solution

Biology Asked by katara on August 11, 2021

If I wanted to utilize hybridization capture for capturing certain genomic regions, I could do it by utilizing complementary probes immobilized on an array or to use the probes in solution and then capture probes using biotin-streptavidin binding.

How do the two compare? Does in solution hybridization e.g. require more probes? What would I need to think about when making my choice?

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