How does aspirin "thin" blood?

Question

As we all know, aspirin doesn't actually thin the blood, as it has been explained to me, it makes it "slippery". Slippery blood doesn't stick to itself hence this helps prevent internal blood clots (or allows blood to pass more easily around an existing clot). I also understand that having your blood too "slippery" can lead to the body attempting to counteract that and making it too "sticky".

Anyhow, my question regarding that is this, how does aspirin work? How does it make the blood "slippery"? (If there is a more medically correct term for "slippery" and "sticky", I'm all ears).

P.S. I paid the Mayo Clinic's website a visit before coming here, the information about aspirin's mechanism wasn't particularly helpful to me.

Chris · Accepted Answer

Aspirine irreversibly inhibits the enzyme cyclooxygenase. This enzyme facilitates the reaction from arachidonic acid to prostaglandin G2/H2. The further reaction leads to the generation of Thromboxane A2 which is important for the activation and aggregation of platelets. See the figure (from here) for an overview:

Thromboxane A2 usually stimulates the activation of new platelets and increases their aggregation, with a shortage of this compound these activations are not possible and the coagulation of blood is reduced.

Rahul Dhillon · Answer

Aspirin  inhibits COX in the endothelium which is required for prostacyclin (PGI2) production. PGI2 is an anti aggregant and vasodilator  . Aspirin also inhibits thromboxaneA2 ( TXA2) production in the platelets. TXA2 is a platelets aggregant and vasoconstrictor hence antagonist of PGI2.
So aspirin decrease both PGI2 and TXA2 production but endothelium cells  can reproduce new COX inside them hence can quickly come over the inhibition of aspirin while platelets can't reproduce new COX so once they are inhibited then they can come over this inhibition only when new platelets are produced in the bone marrow so it takes too much time .
So what aspirin does it that it shifts the PGI2-TXA2 equilibria towards PGI2 so reduce platelets aggregation. Hemostasis , Harper 31st edition.
https://www.webofpharma.com/2021/02/harpers-illustrated-biochemistry-31st.html?m=1

How does aspirin "thin" blood?

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