How do adenoviruses interact with muscle tissue that it makes them acceptable as vector viruses?

From what I understand certain attenuated adenoviruses are popular as a vector virus, meaning a virus that is used as the active agent in a vaccine to infect cells and trigger a helpful immune response.

Of course, this use assumes that the vector virus can indeed infect cells and cause them to replicate the target protein in the first place. From what I can tell, how adenoviruses attach to cells and their receptors is imperfectly understood and furthermore live adenoviruses seem to often prefer infecting cells in organ tissue, not muscle tissue, so what makes researchers confident that adenoviruses are effective as vector viruses when injected into a muscle?