Bioinformatics Asked by Guy Coder on October 1, 2021
In creating a parser for the UniProt flat file uniprot_sprot.dat
(directory) in the manual for the comments POLYMORPHISM
there are listed patterns for alleles, e.g. for 1A11_HUMAN
is
The following alleles of A-11 are known:
A*11:01 (A-11E), A*11:02 (A-11K), A*11:03, A*11:04, A*11:05 and A*11:07.
I tried searching for a description of the patterns using the words allele
and/or polymorphism
and found nothing.
The answer does not have to explain the specifics of the example given.
Example of explanation of other allele pattern from here
This explanation of the patterns doesn’t explain the part of the pattern in UniProt like (A-11E)
.
These are cytotoxic T-cell HLA alleles. HLA genotyping is very common and easy to do, so Genbank is the repository.
A*11:01 has very high frequency in Aborigine populations here . You can explore the population genetics and the past, present and current population genetics distributions per population of HLA at http://www.allelefrequencies.net/
Answered by M__ on October 1, 2021
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