What debuffs are available for temporarily reducing SPECIAL stats?

This list is not exhaustive but should work for most:

• Strength: Daytripper
• Perception: Fury, Drugged water from HalluciGen*
• Endurance: Buffout addiction
• Charisma: Daddy-O
• Intelligence: Alcohol of any kind. For example Whiskey.
• Agility: Med-X addiction, Overdrive addiction, Calmex addiction
• Luck: Daytripper addiction, or equip Tattered Rags**

It should also be noted that X-Cell addiction will debuff ALL stats by -1

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_{* Drugged Water from Hallucigen gives a stackable -1 PER de-buff
** Tattered Rags have a hidden -1 LCK de-buff}

I just tried it. Using addiction debuff along with the SPECIAL cheat does not work. I tried this for strength, endurance, and agility with no result. What does work is using the chems that have an immediate stat reduction such as Day Tripper and Fury. This will only work for strength, charisma, intelligence, and perception, but using the proper chems and the SPECIAL cheat will work. Then you can get the bobblehead for another further +1. You can always take the perk based bonuses such as Solar Powered and Night Person as well, but until the DLC and mods come out that is the best I think anyone can do who has an Xbox One or PS4.

Tattered Rags also work. All addictions I've had so far to Psycho, Med-X, Buffout, Mentats, Jet and Alcohol all have had no effect. But what does seem to work is being drunk or on the drugs that debuff you while you do it. I'd assume to max out your specials the most you could combine debuffs from clothing plus drugs/alcohol at the same time to further the effect before getting any bobbleheads. My question is what drugs/clothing debuff you?

One surefire way to get SPECIAL stat debuffs is to get addicted to a chem and go into withdrawal.

Below is a list of which chems produce a debuff to each special stat, and how much if not just -1. This is based on the screenshot Pierre-Luc Pineault put up in his excellent answer to "How many chem addictions are in Fallout 4?"

Something else relevant to note from that post, is that combination drugs like Bufftats addict you to the drug indicated by the prefix. Buffout, in the case of Bufftats.

• Strength: Psycho, X-Cell, Fury, Buffout, Overdrive
• Perception: X-Cell, Calmex (-2), Fury, Daddy-O
• Endurance: X-Cell, Buffout
• Charisma: X-Cell, Daytripper, Mentats, Alcohol
• Intelligence: X-Cell, Daddy-O
• Agility: X-Cell, Calmex (-2), Overdrive, Med-X, Alcohol
• Luck: X-Cell

Some players here have confused the terms 'addicted' and 'withdraw'. For example, I had a base agility of 10. Using x-cell (x4 as it rate as one of the most addictive) I used them while I stood in front of the agility bobblehead... WAIT for x-cell effects to wear off (a few minutes). At this point you will suffer from withdraw of x-cell giving -1 to agility. With my agility at 9, I grabbed the bobblehead. Now my agility shows 10, but I'm still in withdraw so I remove the addiction, 11 agility.

In order to increase stats past 10 with bobble heads you don't need to do anything other than having your stat at 10 naturally when you pick up the bobble head. No need to mess with debuffs.

The debuffs are only needed to increase a stat past 10 with the S.P.E.C.I.A.L. book from sanctuary.

Beyond that, I found a debuff that will work for agility and endurance and is easier to use than the withdrawal debuff from a drug (which wasn't working for me to increase agility anyway).

Simply make your character over loaded and it will reduce your agility and endurance by -2. This is particularly nice since it's incredibly easy to do.