Arduino Nano 33 Sense won't upload

When I try to upload an example code from the Arduino_LSM9DS1 Library it either jumps ports so the upload cannot complete or spits out some red text and never completes the upload, just gets stuck on uploading.

The red text is:

processing.app.debug.RunnerException
    at cc.arduino.packages.uploaders.SerialUploader.uploadUsingPreferences(SerialUploader.java:152)
    at cc.arduino.UploaderUtils.upload(UploaderUtils.java:77)
    at processing.app.SketchController.upload(SketchController.java:732)
    at processing.app.SketchController.exportApplet(SketchController.java:703)
    at processing.app.Editor$UploadHandler.run(Editor.java:2047)
    at java.lang.Thread.run(Thread.java:748)
Caused by: processing.app.SerialException: Error touching serial port 'COM5'.
    at processing.app.Serial.touchForCDCReset(Serial.java:107)
    at cc.arduino.packages.uploaders.SerialUploader.uploadUsingPreferences(SerialUploader.java:136)
    ... 5 more
Caused by: jssc.SerialPortException: Port name - COM5; Method name - openPort(); Exception type - Port busy.
    at jssc.SerialPort.openPort(SerialPort.java:164)
    at processing.app.Serial.touchForCDCReset(Serial.java:101)
    ... 6 more

I’m not that new to Arduino but I’ve never looked into uploading (I guess I should) and am struggling to get it to work.

Any help is appreciated, thanks