Does the lack of evidence for proton decay really rule out the basic grand unification theories?

Grand unification theories (GUT), such as $SU(5)$/$SO(10)$/SUSY variants, suggest proton decay. The lack of observational evidence for proton decay is supposed to rule out basic GUTs, at least for the basic $SU(5)$ GUT.

But does the lack of evidence for proton decay really rules out the basic grand unification theories?

The GUT’s prediction of proton half-life is based on the assumption that the primary channel of proton decay in GUTs is usually "proton to electron/positron and meson", which is actually predicated on the assumption of $(e, nu_e, u, d)$ being in the same generation.

However, according to Cosmas Zachos’s comment on another PSE post, there is NO established generational linkage between up/down quarks (making up the proton) and electron/position. The standard generation assignment
$$
(e, nu_e, u, d)
(mu, nu_mu, c, s)
(tau, nu_tau, t, b)
$$
is essentially arbitrary: the only rational of the above generation assignment is the relative magnitudes of masses.

If we adopt an alternative generation assignment, say
$$
(mu, nu_mu,u, d)
(tau, nu_tau, c, s)
(e, nu_e, t, b)
$$
the standard model is still working fine as usual.

If the alternative generation assignment is true, and assuming that GUT transition processes involving GUT gauge interactions are generation preserving (meaning not changing between different particle families), then proton should decay into antimuon, rather than positron. And this means that the proton half-life is longer than envisioned before, since muons are much heavier than electrons.

If this is the case, does it mean that the lack of observational evidence for proton decay might NOT disprove simple GUTs?

There are two kinds of counter arguments to the reasoning above:

1. $(e, nu_e)$ and $(u, d)$ have to be grouped together, since the quantum chiral anomaly cancellation conditions demands so. But the quantum chiral anomaly cancellation conditions require that there are same numbers of quark generations and lepton generations. Does anomaly cancellation really preclude the generation grouping of $(mu, nu_mu,u, d)$?
2. In simple GUTs both electron and muon decays will happen, therefore generation assignment does not matter. However, in the case usual generation assignment, the electron channel decay is NOT suppressed, while the muon channel decay is suppressed due to the dimension 6 nature of the muon channel. Therefore the lack of evidence for proton decay indeed rules out the basic grand unification theories. Whereas in the case of the above alternative generation assignment, BOTH of the electron and the muon channels are suppressed, therefore the does the lack of evidence for proton decay necessarily rule out the basic grand unification theories?