What are the differences between "what is with", "what is up with" and "what is wrong with"?

Question

I am watching the drama called Friends at the moment and many times actors used to say one of them. I think it seems like that those expressions are little bit similar to each other.

Please, tell me how those expressions are different.

Thank you in advance.

Marycasia · Answer

“What is up with” is a more positive approach and more polite whereas “what is wrong with” is negative. We use the later for unpleasant things and happenings or expect unpleasant outcome. Having doubts etc.. 
What is up with Mark? He’s not home yet. 
What is wrong with Mark? He’s not home yet.

What are the differences between "what is with", "what is up with" and "what is wrong with"?

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