Do Structure Blocks in Minecraft Save Permanently?

I use Windows 7 and I’m starting to use minecraft structure blocks, as I have a hard time finding resources in certain biomes, and I’m not willing to wander far enough to find a biome that has them in peaceful mode. With the structure block, I have seen tutorials on how to use it, but none of them I’ve seen/read have covered if the structure block can save permanently. I would like to know if I have to save the structure before I exit the application, or if it will remember the file it saved the structure to. I’ve read that using redstone to save structure will only save it to memory, but not to a file or the disk, and that memory takes priority over file, but I don’t understand what this means. If I wanted to save the structure, destroy the original structure block, close the window, relaunch Minecraft and open the world again, would I still be able to load the structure? If I were to shut down the computer, would I still be able to load the structure again?